Homocysteine, Cobalamin and Folate Status and their Relations to Neurocognitive and Psychological Markers in Elderly in Northeastern of Iran

نویسندگان

  • Abbas Shirdel Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Amireh Nejat shokohi Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Habibollah Nemati Karimooy Department of Neurology and Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • jamshid Jamali Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Lida Manavifar Department of Laboratory Sciences Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mahdie Fatemi nayyeri Birjand University of Medical Sciences, Birjand, Iran
  • Morteza Talebi doluee Department of Emergency Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده مقاله:

      Objective(s): Incidence of neurocognitive and psychological disorders may be related to serum homocystein (Hcy), cobalamin (vitamin B12 ) and folate levels in old people. The aim of this study was to assess the relation between Hcy, cobalamin, folate and neurocognitive and/or psychological disorders in the elderly.   Materials and Methods: In this cross-sectional study, 280 subjects with ≥ 65 years old, were evaluated. The subjects were selected from 12 regions of Mashhad, Iran, over March to October 2009. After blood sampling, data were collected by questionnaire, face to face interview and performing neurocognitive and psychological tests. The sera of 250 persons were analyzed for cobalamin and folate by RIA method. Amongst the aforementioned samples, 78 cases with cobalamin Results: Amongst the people, 126 (45%) were male and 154 (55%) were female. The prevalence of hyperhomocysteinemia (HHcy) was 59.5% and 37.1% in male and female respectively (P -value =0.049). Hcy inversely correlated to cobalamin (r=-0.282, P=0.014) and to folate (r=-0.203, P=0.014). Hcy, cobalamin and folate correlations to neurocognitive and psychological impairments were not statically significant. Conclusion: Hyper Hcy or low cobalamin and folate in the elderly, are prevalent but their relationships with neurocognitive and psychological impairments is controversial. If these relationships had been confirmed, performing a single serum Hcy or cobalamin test would have been enough to diagnose and prevent neurocognitive impairments and inversely, neurocognitive-psychological sign and symptoms could have meant probable tissue vitamin deficiencies. However methods of assessing neurocognitive and psychological markers with validity and reliability of clinical and laboratory tests for finding aforementioned relationships should be revised.  

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

homocysteine, cobalamin and folate status and their relations to neurocognitive and psychological markers in elderly in northeastern of iran

objective(s): incidence of neurocognitive and psychological disorders may be related to serum homocystein (hcy), cobalamin (vitamin b12 ) and folate levels in old people. the aim of this study was to assess the relation between hcy, cobalamin, folate and neurocognitive and/or psychological disorders in the elderly.   materials and methods: in this cross-sectional study, 280 subjects with ≥ 65 y...

متن کامل

Homocysteine, Cobalamin and Folate Status and their Relations to Neurocognitive and Psychological Markers in Elderly in Northeasten of Iran

OBJECTIVE(S) Incidence of neurocognitive and psychological disorders may be related to serum homocystein (Hcy), cobalamin (vitamin B12) and folate levels in old people. The aim of this study was to assess the relation between Hcy, cobalamin, folate and neurocognitive and/or psychological disorders in the elderly. MATERIALS AND METHODS In this cross-sectional study, 280 subjects with ≥ 65 year...

متن کامل

individual qualities and integrative motivation and their prediction of non-linguistic outcomes of learning english in intermediate iranian students: a psychological perspective

abstract this study investigated the predictability of variables from a motivational framework as well as individuals qualities to predict three non-linguistic outcomes of language learning. gardners socio-educational model with its measures has been used in the current study. individual qualities presented in this study include (1) age, (2) gender, and (3) language learning experience. the...

role of cultural iran in promotion of multilaieralism in central asia and caucasus

cultural iran is a scope that is more extended than the political territories of iran as a political unit. this concept means that cultural geography(mehdi moghanlo-1383-1) of iran is greater than its political geography which, according to history, has a long history extending west-east from kandahar to the euphrates and north-south from the persian gulf to the caucasus including transoxiana a...

15 صفحه اول

evolutionary origin and phylogenetic relationships among fusarium oxysporum f. sp. melonis isolates in iran and their relationship with nonpathogenic isolates

پژمردگی فوزاریومی خربزه و طالبی با عامل fusarium oxysporum f. sp. melonis از بیماری های مهم قارچی در مناطق رشد این گیاهان می باشد. جدایه های f. oxysporum از گیاهان و خاک ریزوسفر متعلق به پنج استان مهم تولیدکننده ی خربزه و طالبی جداسازی شد و بر پایه ی بیماری زایی در ارقام افتراقی، گروه های سازگاری رویشی (vegetative compatibility groups)، توالی سنجی ناحیه ی جداکننده ی بین ژنی دی اِن اِی ریبوزومی (n...

15 صفحه اول

ec adoption and critical success factors of ec in smes in iran

تجارت الکترونیکی شیوه اجرای مسئولیتها، تقابل با مشتریان و امور معمول عملیاتی در شرکتها را تغییر داده است. تجارت الکترونیکی در عمل تنها خرید و فروش کالاها را از طریق ابزار الکترونیک نمی باشد، بلکه تمام فعالیتهای لازم جهت انجام فرایند فروش را نیز در بر میگیرد. در اواخر دهه 1990 بسیاری از شرکتها فعالیتهای خود را به منظور دستیابی به مشتریان جدید و یا ارائه فرصتهای جدید به مشتریان موجود گسترش دادند...

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 16  شماره 6

صفحات  772- 778

تاریخ انتشار 2013-06-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023